Aging may be a program, not a breakdown

(quantamagazine.org)

40 points | by elo2000 1 hour ago

16 comments

  • anonporridge 44 minutes ago
    It's probably a bit of both.

    Maintaining order and fighting entropy is hard, but also planned obsolescence is a good thing for systemic resilience.

    You have to regularly clear out the old for at least two reasons...

    a) keep the process of creating new things well exercised. "We can't build that anymore. We don't know how." A factory that builds things that last too long eventually goes out of business.

    b) prevent old things from monopolizing resources due to more time to compound interest. Otherwise, you end up with Saturn devouring his son.

    • butlike 30 minutes ago
      I never considered the compound interest angle. This helps me reason about my life; thanks!
      • curuinor 23 minutes ago
        because of the immortality of financial accounts and such, it's basically what's happened to the economy. ancient 100, 200-year-old trusts choking the viability of laborers doing anything and so on. especially bad in europe.
        • anonporridge 18 minutes ago
          It's not just modern finance.

          A tree experiences compounding interest. The longer it lives, the more ground it owns and the more its tall branches and leaves blot out the sun below, making it extremely difficult for any juvenile of its species to take root and mature beneath it.

          This is why some conifers have pine cones that only release seeds when burned in a fire. For these species, evolution has determined it's not even worth trying to germinate unless it's likely a fire killed its parents and made space for them to grow. This is part of how we discovered wildfires are a critical part of some region's ecology. We managed to halt most forest fires and it ruined the natural rhythm of life there.

          • coolThingsFirst 4 minutes ago
            No need to wait, you can die now to make room for those younger.
    • fsckboy 20 minutes ago
      most of human evolutionary history was hunter gatherer and survival was subsistence level, and your arguments don't work.

      birthing was necessary at least to maintain population, but preferably to expand it. it's only now that we consider "too many" a possibility, and we didn't evolve for this moment.

      our history does not show potentially perpetually compounding gains that our children would evolutionarily need a genetic defense against, we already had looting, stealing, and killing.

      I think the answer, if there is a programmed obsolesence, is because the genetic admixing of the next generation through sexual reproduction is so useful and important.

  • aeturnum 46 minutes ago
    There are animals that don't "age"[1] so of course it's programmed. There's a balance between how often you want to recombine genetics and how long you want to be able to remember. It seems like a better system would have humans decline differently (i.e. no dementia) but having people grow old is almost certainly beneficial to the species.

    [1] Their risk of death does not increase after reaching adulthood. I.e. every year after adulthood has the same risk of unexpected death. Humans and other animals that age have their risks of death climb in "old" age.

    • noosphr 34 minutes ago
      The animals are wildly simple however. It may well be that ageless is only possible before you develop a brain.
    • manyatoms 41 minutes ago
      What are examples of non-aging animals?
      • gavinray 39 minutes ago
        The Immortal Jellyfish, and functionally the naked mole rat.
        • tgv 31 minutes ago
          That you can go 300km/h in an F1 car, doesn't mean you can go that fast on a bicycle, even though they're both in the genus "wheel-based vehicles for human transport". The jellyfish is a rather different animal. Trees can grow very old, but there's a reason why you didn't use those as an example: too far from human biology. That jellyfish may be at a similar distance.
          • asdff 19 minutes ago
            We have the ability to convert to becoming immortal. It actually happens to some of us. It sucks though. We call this cancer. Turns out the immortal cells become selfish. But you can scrape some off yourself, throw them in a petri dish, supplement growth media, and they will divide forever.
          • pixl97 27 minutes ago
            The process of science is to determine what exactly these inferred limits actually are and how many can be overcome.
        • moffkalast 32 minutes ago
          The lobster, though they die from being too large to molt.
      • emptybits 22 minutes ago
        IANAB but lobsters are worth a look. They apparently do not get slower or weaker or even lose fertility as they age. And apparently Greenland Sharks might live for 300-500 years, are immune to cancers, and their DNA can repair itself. Maybe leaving the ocean was our ancestors' mistake.
      • cableshaft 37 minutes ago
        [dead]
  • ____tom____ 8 minutes ago
    In biology, there are always many causes, of course.

    I wonder if people are familiar with the hypothesis of parasite-driven aging.

    Parasites are vastly more prevalent than most people in modern, sanitary, medicated societies realize. Studies show that over half the biomass in a region may be parasitic.

    Parasite frequently keep the host alive, but inhibit reproduction. This leaves the host alive, and competing with healthy members of its species for resources, but no capable longer reproducing. It's evolutionary dead weight.

    Death is basically "turning it off and on again", just as you would do with a computer, and for very similar reasons. It clears the accumulated parasites and starts fresh.

    This would also help explain why death is strongly conserved.

  • jvanderbot 45 minutes ago
    I've always thought eternal life would steal from the next generation if resources are scarce. If your reaction times, intelligence, etc are always good, and your experience and memories get better, it just seems like you'd out compete your kids and younger cohorts. All well and good but basically stops genetic turnover that got us to this point.

    OTOH, you'd accumulate uncurable disease, injuries, etc as well. Maybe you become a disease resevoir inside your own growing family. Or you pass on as-yet-unknown genetic anomalies that are unhelpful, and you do so forever.

    Granted that's a modern take, and in particular a modern rpg-like take. Regardless though getting rid of oldies seems like a reasonable way to move a species forward if natural selection is driving "forward".

    • mjburgess 40 minutes ago
      OTOH a vast amount of mayhem and madness arises just from each generation's memory being wiped clean. Within three or four generations the earth lacks any sense of what risks came before it, and repeats the same stupid stuff.

      If we were managed by the interwar generation, little of what's happening today would be happening today.

      • anonporridge 37 minutes ago
        That goes both ways.

        Lack of experience is critical for risk taking. Even great successes like Jensen Huang have said that if they knew how hard it was going to be, he wouldn't choose his path again.

        Memory blocks you from experimentation as much as it protects you from making recurrent mistakes. A species or civilization with too much memory will eventually wither away towards complete inaction and decay.

        • asdff 17 minutes ago
          There seems to be a balance point with the number of Chesterson's fences. Too many and you are penned in or routed on one vector only. Too few and you are blind.
        • pixl97 26 minutes ago
          Yep, it allows you to climb out of local maxima.
          • asdff 15 minutes ago
            Only if it works. Evolution works like this with local fitness maxima and wells of stability favored by entropy. You have to luck out with the right combination of mutations to not only get out of that well but fall into one of lower entropy. Imagine the size of the search space required for something like this. This is why evolution is "slow" in species that live as long as us and quite rapid in things that grow logarithmically by the hour.
      • pixl97 30 minutes ago
        >the earth lacks any sense of what risks came before it

        The earth is a bad term here, how about human civilization?

        Your DNA, epigenetics, and a ton of other subconscious intelligent processes are well aware of the risks and contain a massive set of tools to overcome them.

        The problem? Many of these tools have to run from zero in an egg to work in the changing environment.

      • _doctor_love 28 minutes ago
        > If we were managed by the interwar generation, little of what's happening today would be happening today.

        Doubtful. They were the ones who created the world we live in today.

      • moffkalast 34 minutes ago
        OTOH same is true for wiping clean habits, prejudices and deeply held wrong beliefs. It's said that science advances one funeral at a time.

        If we were managed by the colonial generation, slavery and segregation would still be the norm, only rich white men would be able to vote and a king would still have the final say.

    • ainch 19 minutes ago
      There's the saying in science that progress happens 'one funeral at a time,' but that's not because older scientists are less intelligent - it's more like they begin to intellectually ossify. Or in the arts, the critics that rejected Matisse's 'Woman With a Hat' weren't stupid, but their thinking had stagnated.

      I think we underrate the value of a fresh perspective. People living longer lifespans would dilute that benefit, imo. Sidenote: this is also an underrated issue with LLMs and their application to science - collapsing to single modes of thought over time.

    • Arubis 27 minutes ago
      > I've always thought eternal life would steal from the next generation if resources are scarce.

      This is almost the stated intention of longevists.

    • pavel_lishin 38 minutes ago
      > If your reaction times, intelligence, etc are always good, and your experience and memories get better, it just seems like you'd out compete your kids and younger cohorts.

      On the other hand, always being around as a sort of Protector to protect your kids seems like it would generally be good for your genes. (Of course, you'd have to fight off other Protectors who are doing the same...)

      • noosphr 27 minutes ago
        This is where being a real parent vs a theoretical one makes a huge difference to your take. After seeing how much damage to their kids people adapted _their_ childhood do, I've started to think that humans should die around 40 with reproduction age being between 10 to 20 - like most other great apes. It's only in increadibly stable environments that waiting for as long as we do for children that it makes sence.

        How this number is going to change in the future with exponential growth in the environment is left as an exercise to the reader.

      • Kirth 36 minutes ago
        Finally mankind can return to it's intended 3-phase form of existence as described by Niven
      • jvanderbot 27 minutes ago
        Right, but should your kids get your protection? You can protect them to adulthood now, even your grandkids.

        But 1000 generations of unassailable, un-evolving, 40IQ lions doesn't get you to the galaxy.

        Hey, maybe this is the fermi paradox.

      • SoftTalker 35 minutes ago
        Not if that protection ended up making your offspring weaker. Some adversity is necessary to develop resilience and self-sufficiency.
      • mnem 37 minutes ago
        One's kids may disagree.
      • anonporridge 36 minutes ago
        Imagine still having helicopter parents at 50 years old.
        • readthenotes1 25 minutes ago
          My granddad tells the story of the time he left his parents house and they called out "Make sure to turn your burners on".

          He was in his 60s....

          Once a parent, always a parent, I guess.

    • _doctor_love 30 minutes ago
      > getting rid of oldies seems like a reasonable way to move a species forward

      This is the real feature of aging, death, and dying. Progress is measured in funerals, not years. If everyone lived forever, nothing would ever change.

      • bilbo0s 13 minutes ago
        >nothing would ever change

        Including our fundamental biology.

        If we want a chance at improved, more resilient biology, aging and death have to be a part of that.

        • _doctor_love 7 minutes ago
          Aging and death should be a more discussed and comfortable topic for people. Death and dying is natural, just as is being born.
    • bitwize 40 minutes ago
      Sounds like an argument for pacing the frontier of geriatric medicine.
  • dmillar 11 minutes ago
    25 years ago I had a spirited discussion with my AP Biology teacher where I posited a similar theory when we were discussing (and running experiments on) genetic mutations. It was "spirited" because she was rather dismissive of the idea, and my (likely overconfident) teenage brain did not understand her response and reasoning. She was otherwise a great teacher.

    There's been several articles over these last decades that have covered different iterations of genetic aging, and I think about that discussion every time. I wonder if she's read any of them and also thought about that discussion.

  • thinking_cactus 19 minutes ago
    I think death has some actual benefits. Yes, some of our comfort with death comes with learning to live with its inevitability, but it has genuinely some upsides. I think they have some to do with being able to change things and institutions, but mostly it centers around our brains and psychology. Our life cycle is connected to how our brain develops and matures, inherently I think.

    For example, if you go through some events in your childhood, they may stick with you until your death, as an inevitable part of you. Sure, treatment helps, but probably some memories you can't just erase.

    Recycling things into a next generation, with probably better living conditions seems like generally pretty positive thing.

    Also, some time you'd probably start to stop learning, not necessarily due to brain aging and neuron death, but simply because of basic architecture of our brain and how information solidifies and it starts to become more difficult to learn new things. We are a little more bored of most things and a lot of mystery and wonder diminishes somewhat.

  • rglover 25 minutes ago
    Reminds me of a thought I had about galaxies being instance runs while writing Github actions to build database binaries.

    Each galaxy and any planets/life it contains are just artifacts of an "existence run." That's why life feels like a simulation so often (and human history repeats itself): we're inside of an organic (human word) "program" that's trying to perfect itself by running similar, but consistently tweaked "logic" over and over (a macro of sorts). Things like evolution are just an algorithm embedded in the system.

    If the theory discussed in the article is correct, then aging is (in the scope of the above thought) just one program among several that we interpret as existence/life.

    Just a daydream but fun to think about.

  • marojejian 30 minutes ago
  • silverFork 42 minutes ago
    Not surprised. Some sort of optimization program to terminate the aged in order to reduce the maintenance issues for the next generation I suppose..
    • SoftTalker 33 minutes ago
      And the mandatory need for replacement keeps mixing the gene pool, occasionally producing improvements.
      • bilbo0s 20 minutes ago
        This is the real answer. Nature only cares that the old already mixed their genes. So, from an evolutionary biology perspective, it's good to clear out the old stock at the end of every generation. Nature already got whatever it was gonna get out of us at that point. To allow that set of genes to stick around actually yields negative returns, ie - less chance of producing improvements, at that point. (Again, just from the perspective of "Mother Nature" so to speak. Obviously the animals themselves would rather not die.)
        • asdff 7 minutes ago
          Mother nature has no perspective. There are no improvements either, only things that are and are not. Everything is dependent on local context at the present point in time and framing whether it is "good" or "bad" (e.g. one could frame our intelligence as good or bad given how it resulted in anthropocentric climate change that may doom us in time, while 'dumber' species have existed for millions of years without wiping themselves out).

          What works today may not work tomorrow. What didn't work yesterday may work today. Evolution is not linear. It tends to happen in bursts almost like a dam busting loose. A constant cycling between periods of genetic diversity (i.e. big resetting just happened, no winners taking all quite yet), and what is known as allele fixation (a winner emerged, oh god no...).

  • irdc 46 minutes ago
    Aging could very well be a program to deal with the breakdown.
    • asdff 1 minute ago
      It very much is. We have a term for cells that escape immune surveillance to cull them off when they are broken: cancer cells.
  • pavel_lishin 39 minutes ago
    Any Larry Niven fans nodding along?
  • addaon 35 minutes ago
    You could even say it's an "upgrade Pak."
  • onesandofgrain 23 minutes ago
    It’s an accumulation of damage. End of story.
  • jdw64 31 minutes ago
    In the end, can aging itself not be cured, and is the only option to prevent the program that causes it? I'm curious
  • AndrewKemendo 44 minutes ago
    >when he became acutely aware that his grandparents and parents were not going to live forever…Cao turned to science. Finding a way to slow aging became his lifelong goal

    Nothing is supposed to persist forever it doesn’t even make sense to try

    • geodel 40 minutes ago
      I wonder what Cao would've done once he learned that his great-grandparents are already gone. Perhaps at that point nothing less than time machine invention will do.
    • the_af 35 minutes ago
      > Nothing is supposed to persist forever it doesn’t even make sense to try

      "Supposed" by whom?