Popular gut probiotic craps out in randomized controlled trial

(arstechnica.com)

48 points | by zdw 1 day ago

9 comments

  • njtransit 23 hours ago
    It’s interesting that both groups had their number of bowel movements double or more. Perhaps a lot of constipation is actually dehydration.
    • Nifty3929 23 hours ago
      If you take one of these little pills with a large glass of water for every alcoholic beverage you drink, then it will prevent hangovers.
    • mirekrusin 23 hours ago
      Like this magic pill to loose weight that you need to take before every meal with large glass of water, where pill is optional.
      • tyre 23 hours ago
        or Emegen-C or hangover cures
  • the_sleaze_ 1 day ago
    Best gut related health I ever had was living in France and eating stinky raw cheeses and different fermented foods. Like clockwork.
    • darth_avocado 1 day ago
      There’s two different effects hidden in that statement

      > living in France

      I have had similar experience where my gut health was immediately, noticeably better in Europe. I was eating the same foods and somehow it was better.

      > Eating stinky raw cheeses and different fermented foods

      Raw and fermented foods in cultures across the world are linked to better gut health. However, industrial fermentation and packaging won’t help you as much because the diversity of microbes drops and packaging often kills most of them. We need to bring back the culture of home fermentation.

      • murukesh_s 23 hours ago
        >I have had similar experience where my gut health was immediately, noticeably better in Europe. I was eating the same foods and somehow it was better.

        Could be due to you being in a better mental state. Gut-brain axis is very evident for me personally. If I am tense gut is the first to get affected.

      • jonnycomputer 23 hours ago
        I agree about diversity. We use a very limited range of cultures in mass manufactured foods.
      • Brian_K_White 23 hours ago
        But of course can never happen because it only takes a minority to cry about a few factual bad stories and present the fallacious "is it worth it" argument. "Is your epicurian enjoyment worth even one dead baby?" And a majority who have no reason to think much about it go along with it because no one will say "yes it's worth it" and few are able to articulate how the question was invalid in the first place.

        The opposite minority argument, that variety, depth, richness, are important, not luxuries, don't have their own dead babies to present. They do exist, but they aren't visible except in aggregate. You can measure a change in average health over the course of entire generations, and from that you can extrapolate the change in number or frequency of deaths, and then you could compare numbers of dead babies. But you can't obviously show any particular cause & effect because there are so many other variables, and even if you could, it took entire generations whole lives lived and died before they could benefit anyway.

        • tyre 23 hours ago
          okay wow deep breath, you can just ferment things at home, it’s fine, I did it twice last week
      • waihtis 1 day ago
        > my gut health was immediately, noticeably better in Europe

        Its because a lot of the weird artificial junk that are allowed to be put into your food is illegal in Europe. Even things like popular sweeteners have been shown to have a negative effect on your gut health.

        • sroussey 23 hours ago
          The preservatives in flour / bread / etc are illegal in Europe. My sister is allergic and can’t have any bread in the USA. But can in France and Italy.
        • SoftTalker 23 hours ago
          Also non-flouridated, non-chlorinated water.
          • manoweb 23 hours ago
            I lived most of my life in an alpine European village; water was chlorinated and flourinated, more than in my current US location. There was a huge difference in mineral content, US water being almost distilled (1 to 3 French degrees hardness) VS something like 15-20 in Europe
        • hedora 23 hours ago
          Most sweeteners also have been shown to cause more weight gain than sugar (they screw up your metabolism). Unless you’re diabetic, there’s literally no reason to consume them.
          • cenamus 23 hours ago
            I'd like to see a source on that, because (excessive) sugar literally causes diabetes.

            And of course high sweetener consumption is must be strongly linked with in general high calorie input and overweight people trying to reduce calorie consumption.

            • Spivak 23 hours ago
              Your first point probably isn't actually true. The research that first connected the two showed that across a population sugar consumption up -> diabetes rates up. But it turns out that when you control for weight the effect of sugar specifically is much much smaller. To the point where if you're a healthy weight your sweet tooth isn't moving the needle.
          • Spivak 23 hours ago
            Oh that's not true at all. First I think they taste better, they're sweet without being syrup-y. Second it allows me to drink a lot of soda, 5+ cans a day adds up when it has calories. I have no expectation that it helps me lose weight, it's just tastier water.
    • jajko 1 day ago
      My wife recently got Kombucha mushroom from a friend, and got into fermenting it herself. Its trivial to do, you need to really screw up something for it to go wrong, tons of good bacteria inside. She takes some basic precautions like avoiding metal parts (since the drink becomes acidic), otherwise its on autopilot, good bacteria outcompete everything else for resources.

      She mixes it with some cut fruits to get some sugars for fermentation, the result is very mild alcohol content (maybe 0.5%) and it tastes like cider. I mix it maybe 1:3 with water and its semi-eternal homemade drink. Can't really complain.

      That and of course french cheese, we live maybe 5km from French border and for cheese its much better place than even Switzerland (sorry guys gruyere is great but french variety is huuuuge in comparison and they even usually have specialties like old dutch gouda which is taste heaven for me and various truffle-infused ones).

    • m3kw9 1 day ago
      Gotta hit up the cheese fests now
  • mg 23 hours ago
    There is a lot of confusion on how to interpret studies.

    The reasoning of this article seems to be "The study did not produce a significant result, therefore the treatment is ineffective".

    But that is not how to think about significance.

    Otherwise, you could show for any treatment that it is ineffective. By simply doing a study small enough to produce an insignificant result.

  • zdw 1 day ago
    The headline is some of the best output I've recently seen.
    • itronitron 1 day ago
      It's a solid and well-formed contribution.
      • hedora 23 hours ago
        Yeah, but the register is more regular. This one’s been ripening for a decade and is as fresh as the day it was produced:

        https://www.theregister.com/2014/01/20/haribo_gummy_bears_im...

      • hanniabu 1 day ago
        Both of you sound like bots
        • projektfu 23 hours ago
          That was the wrong criticism and your model will need to be retrained. The correct response is "this isn't Reddit".
          • exe34 23 hours ago
            good bot
        • zdw 23 hours ago
          Ah, I'm not definitely not todsacerdoti , who automated reposting all of lobste.rs to HN.

          My pithy comment was actually inspired by Sir Patrick Stewart's interview about his role in the Emoji movie: https://youtu.be/CgAIqP6hNlQ?t=215

    • morkalork 23 hours ago
      Beth Mole is as consistent as ever
  • jonnycomputer 23 hours ago
    For what it's worth, I always thought that yogurts, etc. are better at slowing down digestion/dealing with diarrhea than constipation.
  • XorNot 23 hours ago
    This is about Bifidobacterium animalis subsp. lactis.

    Personally I take L. Reuteri supplements, which for me have made an unbelievable difference in suffering from IBS symptoms (and have some clinical evidence to support having an effect). This was a result a recommendation somewhere else on HN about 2 years ago now, so I'll pass it forward whenever the topic comes up.

    In my experience it took about 3 months to see effects (during which time I did feel somewhat worse), and currently if something happens - i.e. I get sick - then there's a bit of reversion towards feeling bad. But: I was also able to stop taking them for about 6-9 months before it seemed like the effect was diminishing.

    • nyjah 23 hours ago
      I consider myself a disciplined dieter. But no way I could endure 3 months of nothing - maybe being worse - to maybe see some benefits. How did you stay motivated thru those 3 months and any other tips? I’d be curious.
    • graeme 23 hours ago
      Which version of L. Reuteri did you take?
  • trilbyglens 1 day ago
    Should be noted that constipation relief is far from the only benefit that probiotics provide to your gut biome. Healthy gut biome has been linked to lower levels of depression and lots of other things seemingly unrelated.
    • raincole 1 day ago
      > Should be noted that constipation relief is far from the only benefit that probiotics provide to your gut biome.

      You mean claimed to provide.

      • hanniabu 23 hours ago
        Anecdotal but I'm on a very strict diet, to the point where I have the same thing every meal, every day. There's certain probiotics I take that help bowel movements and some that slow things down. It's very repeatable and given I eat the same thing every meal every day and I'm on a regular eating and activity schedule that leaves very little other variables.

        My guess is that for regular people the benefit is insignificant but it's greater for people with issues (dysbiosis).

        And the type of dysbiosis you have will determine the effect of the probiotics. For some it can slow motility or cause constipation and others increase motility or cause diarrhea.

        There's so many internal variables with your gut microbiome and there's a general lack of reliable methods to test your microbiome. This makes tests like these really difficult and also makes it difficult to treat digestion issues. Because of this, all gastro doctors can really do is slap on IBS/IBS label but not really have a course of action with any decent success rate.

    • homebrewer 23 hours ago
      Read the article, placebo was just as effective as these "probiotics".
  • AlbertCory 23 hours ago
    Whenever some theme gets broad advertising, I get suspicious. "Helps boost the immune system!" -- WTF does that mean?

    "Probiotics for gut health!" -- yeah, right. Get back to me in 10 years when you have some actual evidence.

  • spants 1 day ago
    If you want to improve your gut health, stop eating meat and go vegan. But most of you would rather take meds instead.
    • homebrewer 23 hours ago
      Just wondering, have you ever managed to convert or convince a single person by acting like a stereotypical vegan?
      • kstenerud 23 hours ago
        If you're not going to judge people, then why bother at all?
    • loeg 23 hours ago
      There's absolutely no evidence that a vegan diet provides a benefit for gut health relative to a diet including meat.
    • bryant 1 day ago
      If the concern is just meat, why not go vegetarian instead?
      • CapitalistCartr 23 hours ago
        Wearing this leather belt is what's causing my constipation.
      • 2OEH8eoCRo0 23 hours ago
        Because it's more about being an absolutist snob than anything. Vegans don't eat honey. If I have a pet hen I can't eat the eggs? Ridiculous.
      • SoftTalker 23 hours ago
        What kind of vegetarian? Some allow eating eggs and dairy. Some allow fish or even birds.
    • wusher 23 hours ago
      I had the exact opposite experience. when I stopped eating meat I got worse. When I stopped eating vegetables I got better. I’m not saying you shouldn’t eat vegetables, I’m saying your claim isn’t as strong as you think it is and peoples gut issues are different.
      • lepus 23 hours ago
        A lot of people go all in on increasing dietary fiber and then experience gut issues and think it must be the plants when they didn't work into it slowly enough. It's like going to the gym and and feeling sore all over all the time or even getting injured and then concluding that going to the gym is bad when no one told you that you should start easy. In my opinion there's harm in how people fail to communicate how to get started on plant based diets when they miss important issues like this that can permanently put people off from it.
      • dpassens 23 hours ago
        Am I misunderstanding or do you really not eat any vegetables at all, not even in a dish with meat?
    • hanniabu 1 day ago
      Some people have dysbiosis which makes it impossible to have most vegetables
      • shermantanktop 23 hours ago
        People who have things which are exotic, rare, or complicated don’t present some kind of existence proof against advice directed at a general population which doesn’t have those conditions.