3 comments

  • xnx 42 minutes ago
    Many here have expressed skepticism at GLP1s because they don't require the personal discipline of caloric deficit and might have unknown side effects.

    So far, all the unknown side effects I've read about have been like this.

    • andreshb 30 minutes ago
      Lawsuits claiming Ozempic, other GLP-1s led to blindness become second mass litigation over the drugs

      https://www.reuters.com/legal/government/lawsuits-claiming-o...

      • ipsum2 29 minutes ago
        This is from a year ago. Millions of people are on GLP-1s, there's definitely not a mass blindness that's ongoing.
        • declan_roberts 21 minutes ago
          Not to mention the first people on these drugs were type 2 diabetics who are the exact group that's at risk for NEON.

          Think of all the things they're not gonna be at risk for, not being diabetic now.

    • annzabelle 16 minutes ago
      N of 1, but I had serious low drive/motivation side effects from Wegovy. Everything enjoyable became less enjoyable, from alcohol, to running, and after a couple of months, even getting out of bed. I lost weight slower than I had previously with old school calorie counting (most of which I have kept off to this day). Within a couple weeks of getting off it I was back to normal.

      My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.

    • lucianmarin 15 minutes ago
      It's not the caloric deficit, it's the insulin. Cells don't have caloric receptors, only insulin receptors. I created an info site about this. Managing your insulin have the same effects as GLP-1 meds.
      • metadat 5 minutes ago
        Why mention your info site without providing a link? It's a little frustrating to read comments like this. Thank you.
  • nozzlegear 37 minutes ago
    Sign me up for this miracle drug already.
    • declan_roberts 13 minutes ago
      I suspect that there's twice as many people taking RUO versions of it than actual prescriptions.

      You can get the stuff at a mall kiosk now.

  • ChrisArchitect 1 hour ago
    Related:

    GLP-1 may slow biological aging

    https://news.ycombinator.com/item?id=50132328